Dr. Bente Klarlund Pederse of the University of Copenhagen, Denmark, believes that we should spend some of our time training in a glycogen-depleted state in order to maximize our training benefits to increase production of the immune system agent Interleukin-6.

In other words, do some workouts underfueled and make yourself bonk in training.

Pedersen provided some validation for this hypothesis through a clever study in which she had subjects exercise one leg once daily and the other leg twice every other day. The total amount of training was equal for both legs, but the leg that was trained twice every other day was forced to train in a glycogen-depleted state in that afternoon workout. After several weeks of this, subjects engaged in an endurance test with both legs. Pedersen found that the leg trained twice every other day increased its endurance 90 percent more than the other leg.

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